FDA approval in Broad antitumor activity, flexible dosing component of many combination chemotherapy regimens for breast, lung, gastric and ovarian cancers, Hodgkin's disease, non-hodgkin's lymphoma, sarcoma, myeloma, and acute lymphocytic leukemia.
Particularly bad side effect profile: Gradual cardiotoxicity, fatal heart failure Reserachers tried to develop analogs, with lower side effects, but despite reviewing over such molecules, doxorubicin still remained the only choice.
Synthesis: Harrison et al. W C27H29NO 2.
Extruder for preparing small Size liposomess 2. Hiroshi Maeda at Kumamoto University. The EPR effect means that high polymerized drugs and liposomes are selectively trapped by tumor tissues and stay there for a longer period of time because of the following characteristics of tumor tissues: High neovascular density; Insufficient vessel structure, increased permeability for liposomes Decresased lymphatic drain Új ér képződés Lyukak az érfalon, megnövekedett permeabilitás Csökkentett nyirok elfolyás nm miért ideális méret?